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dc.contributor.authorJankovic, Sandra
dc.contributor.authorDitzinger, Felix
dc.contributor.authorKuentz, Martin
dc.date.accessioned2020-02-06T10:40:09Z
dc.date.available2020-02-06T10:40:09Z
dc.date.issued2018-02-28
dc.identifier.doi10.1111/jphp.12948
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/30422
dc.description.abstractObjectivesSolubility parameters have been used for decades in various scientificfields including pharmaceutics. It is, however, still a field of active research bothon a conceptual and experimental level. This work addresses the need to reviewsolubility parameter applications in pharmaceutics of poorly water-soluble drugs.Key findingsAn overview of the different experimental and calculation methodsto determine solubility parameters is provided, which covers from classical tomodern approaches. In the pharmaceutical field, solubility parameters are pri-marily used to guide organic solvent selection, cocrystals and salt screening,lipid-based delivery, solid dispersions and nano- or microparticulate drug deliv-ery systems. Solubility parameters have been applied for a quantitative assessmentof mixtures, or they are simply used to rank excipients for a given drug.SummaryIn particular, partial solubility parameters hold great promise for aid-ing the development of poorly soluble drug delivery systems. This is particularlytrue in early-stage development, where compound availability and resources arelimited. The experimental determination of solubility parameters has its meritsdespite being rather labour-intensive because further data can be used to contin-uously improvein silicopredictions. Such improvements will ensure that solubil-ity parameters will also in future guide scientists in finding suitable drugformulations.en_US
dc.description.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/jphp.12948en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.accessRightsAnonymous*
dc.subjectenabling formulationen_US
dc.subjectin silicopredictionen_US
dc.subjectpoorly water-soluble drugen_US
dc.subjectsolubility parameteren_US
dc.titleApplication of the solubility parameter concept to assistwith oral delivery of poorly water-soluble drugs–a PEARRLreviewen_US
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin*
dc.audienceScienceen_US
fhnw.publicationStatePublisheden_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.InventedHereYesen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.publicationOnlineJaen_US


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