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dc.contributor.authorZhang, K.
dc.contributor.authorFent, Karl
dc.date.accessioned2017-12-18T12:18:08Z
dc.date.available2017-12-18T12:18:08Z
dc.date.issued2018-01-01
dc.identifier.urihttp://hdl.handle.net/11654/25721
dc.description.abstractA highly sensitive and robust method was developed for routine analysis of two progestin metabolites, 17α-hydroxypregnanolone (17OH-Δ5P) and pregnanediol (PD), and 31 other natural and synthetic steroids and related metabolites (estrogens, androgens, corticosteroids, progestins) in river water, as well as influents and effluents of municipal wastewater treatment plants (WWTP) using HPLC-MS/MS combined with solid-phase extraction. For the various matrixes considered, the optimized method showed satisfactory performance with recoveries of 70–120% for most of target steroids. The method detection limits (MDLs) ranged from 0.01 to 3 ng/L for river water, 0.02 to 10 ng/L for WWTP effluents, and 0.1 to 40 ng/L for influents with good linearity and reproducibility. The developed method was successfully applied for the analysis of steroids in rivers and WWTP influent and effluents. WWTP influents concentrations of 17OH-Δ5P and PD were 51–256 ng/L and up to 400 ng/L, respectively, along with androstenedione (concentration range: 38–220 ng/L), testosterone (11–26 ng/L), estrone (2.3–37 ng/L), 17β-estradiol (N.D.–8.7 ng/L), 17α-hydroxyprogesterone (N.D.–66 ng/L), medroxyprogesterone acetate (N.D.–5.3 ng/L), and progesterone (2.0–22 ng/L), while only androstenedione (ADD), estrone (E1), and estriol (E3) were detected in effluent with concentrations ranging up to 1.7 ng/L, 0.90 ng/L and 0.8 ng/L, respectively. In river water samples, only ADD and E1 were detected with concentrations up to 1.0 ng/L and 0.91 ng/L. Our procedure represents the first method for analyzing 17OH-Δ5P and PD in environmental samples along with a large series of steroids.
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S0048969717321125
dc.language.isoen_US
dc.relation.ispartofScience of the Total Environment
dc.accessRightsAnonymous
dc.subjectSteroids
dc.subjectMatrix effects
dc.subjectRiver water
dc.subjectWastewater effluents
dc.subjectTrace analysis
dc.titleDetermination of two progestin metabolites (17a-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, clorticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume610-611
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandYes
fhnw.pagination1164-1172
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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