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dc.contributor.authorZhao, Yanbin
dc.contributor.authorZhang, Kun
dc.contributor.authorFent, Karl
dc.date.accessioned2017-01-23T06:23:24Z
dc.date.available2017-01-23T06:23:24Z
dc.date.issued2016-09-12
dc.identifier.doi10.1021/acs.est.6b03436
dc.identifier.urihttp://hdl.handle.net/11654/24045
dc.description.abstractSynthetic corticosteroids may pose an environmental risk to fish. Here, we describe multiend point responses of adult zebrafish (8 months old) upon 21-day exposure to a commonly prescribed corticosteroid, fludrocortisone acetate (FLU), at concentrations between 0.006 and 42 μg/L. No remarkable reproductive impacts were observed, while physiological effects, including plasma glucose level and blood leukocyte numbers were significant altered even at 42 ng/L. Ovary parameters and transcriptional analysis of hypothalamic–pituitary–gonadal–liver axis revealed negligible effects. Significant alterations of the circadian rhythm network were observed in the zebrafish brain. Transcripts of several biomarker genes, including per1a and nr1d1, displayed strong transcriptional changes, which occurred at environmental relevant concentrations of 6 and 42 ng/L FLU. Importantly, the development and behavior of F1 embryos were significant changed. Heartbeat, hatching success and swimming behavior of F1 embryos were all increased even at 6 and 42 ng/L. All effects were further confirmed by exposure of eleuthero-embryos. Significant transcriptional changes of biomarker genes involved in gluconeogenesis, immune response and circadian rhythm in eleuthero-embryos confirmed the observations in adult fish. Hatching success, heartbeat, and swimming activity were increased at 81 ng/L and higher, as with F1 embryos. These results provide novel insights into the understanding of potential environmental risks of corticosteroids.
dc.language.isoen
dc.relation.ispartofEnvironmental Science and Technology
dc.accessRightsAnonymous
dc.titleCorticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume50
dc.issue18
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination10245-10254
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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