FHNW Fachhochschule Nordwestschweiz
  • Startseite
  • Publikationen
  • Projekte
  • Studentische Arbeiten
  • de
  •  Login
Eintraganzeige 
  •   IRF Home
  • Hochschule für Life Sciences
  • Institut für Ecopreneurship
  • Eintraganzeige
  • Hochschule für Life Sciences
  • Institut für Ecopreneurship
  • Eintraganzeige
JavaScript is disabled for your browser. Some features of this site may not work without it.

Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations

Datum
12.09.2016
Autorin/Autor
Zhao, Yanbin
Zhang, Kun
Fent, Karl
Metadata
Zur Langanzeige
Type
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Primary target group
Science
Created while belonging to FHNW?
Yes
Zusammenfassung
Synthetic corticosteroids may pose an environmental risk to fish. Here, we describe multiend point responses of adult zebrafish (8 months old) upon 21-day exposure to a commonly prescribed corticosteroid, fludrocortisone acetate (FLU), at concentrations between 0.006 and 42 μg/L. No remarkable reproductive impacts were observed, while physiological effects, including plasma glucose level and blood leukocyte numbers were significant altered even at 42 ng/L. Ovary parameters and transcriptional analysis of hypothalamic–pituitary–gonadal–liver axis revealed negligible effects. Significant alterations of the circadian rhythm network were observed in the zebrafish brain. Transcripts of several biomarker genes, including per1a and nr1d1, displayed strong transcriptional changes, which occurred at environmental relevant concentrations of 6 and 42 ng/L FLU. Importantly, the development and behavior of F1 embryos were significant changed. Heartbeat, hatching success and swimming behavior of F1 embryos were all increased even at 6 and 42 ng/L. All effects were further confirmed by exposure of eleuthero-embryos. Significant transcriptional changes of biomarker genes involved in gluconeogenesis, immune response and circadian rhythm in eleuthero-embryos confirmed the observations in adult fish. Hatching success, heartbeat, and swimming activity were increased at 81 ng/L and higher, as with F1 embryos. These results provide novel insights into the understanding of potential environmental risks of corticosteroids.
URI
http://hdl.handle.net/11654/24045

Stöbern

Gesamter BestandBereiche & SammlungenErscheinungsdatumAutoren/AutorinnenTitelThemenDiese SammlungErscheinungsdatumAutoren/AutorinnenTitelThemen

Mein Benutzerkonto

EinloggenRegistrieren

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

Kontakt

Fachhochschule Nordwestschweiz FHNW
Vizepräsidium Hochschulentwicklung
Bahnhofstrasse 6
5210 Windisch

E-Mail: irf@fhnw.ch

Über das IRF

Das IRF ist das digitale Repositorium der Fachhochschule Nordwestschweiz FHNW. Es enthält Publikationen, studentische Arbeiten und Projekte.

Links

Liste der IRF Power User
Feedbackformular

www.fhnw.ch | Impressum | Datenschutz | Urheberrecht