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dc.contributor.authorCampinez, Maria Dolores
dc.contributor.authorCaraballo, Isidoro
dc.contributor.authorPuchkow, Maxim
dc.contributor.authorKuentz, Martin
dc.date.accessioned2016-12-13T10:43:19Z
dc.date.available2016-12-13T10:43:19Z
dc.date.issued2016
dc.identifier.issn1530-9932
dc.identifier.doi10.1208/s12249-016-0613-0
dc.identifier.urihttp://hdl.handle.net/11654/23690
dc.description.abstractThe aim of the present work was to better understand the drug-​release mechanism from sustained release matrixes prepd. with two new polyurethanes, using a novel in silico formulation tool based on 3-​dimensional cellular automata. For this purpose, two polymers and theophylline as model drug were used to prep. binary matrix tablets. Each formulation was simulated in silico, and its release behavior was compared to the exptl. drug release profiles. Furthermore, the polymer distributions in the tablets were imaged by SEM (SEM) and the changes produced by the tortuosity were quantified and verified using exptl. data. The obtained results showed that the polymers exhibited a surprisingly high ability for controlling drug release at low excipient concns. (only 10​% wt.​/wt. of excipient controlled the release of drug during almost 8 h)​. The mesoscopic in silico model helped to reveal how the novel biopolymers were controlling drug release. The mechanism was found to be a special geometrical arrangement of the excipient particles, creating an almost continuous barrier surrounding the drug in a very effective way, comparable to lipid or waxy excipients but with the advantages of a much higher compactability, stability, and absence of excipient polymorphism.
dc.language.isoen
dc.relation.ispartofAAPS PharmSciTech
dc.accessRightsAnonymous
dc.subjectPharmaceuticals
dc.titleNovel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.audienceScience
fhnw.publicationStatePre-Print
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination-
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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