Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Primary target group
Created while belonging to FHNW?
The aim of the present work was to better understand the drug-release mechanism from sustained release matrixes prepd. with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular automata. For this purpose, two polymers and theophylline as model drug were used to prep. binary matrix tablets. Each formulation was simulated in silico, and its release behavior was compared to the exptl. drug release profiles. Furthermore, the polymer distributions in the tablets were imaged by SEM (SEM) and the changes produced by the tortuosity were quantified and verified using exptl. data. The obtained results showed that the polymers exhibited a surprisingly high ability for controlling drug release at low excipient concns. (only 10% wt./wt. of excipient controlled the release of drug during almost 8 h). The mesoscopic in silico model helped to reveal how the novel biopolymers were controlling drug release. The mechanism was found to be a special geometrical arrangement of the excipient particles, creating an almost continuous barrier surrounding the drug in a very effective way, comparable to lipid or waxy excipients but with the advantages of a much higher compactability, stability, and absence of excipient polymorphism.