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dc.contributor.authorShah, Ashesh
dc.contributor.authorCoste, Jérôme
dc.contributor.authorLemaire, Jean-Jaques
dc.contributor.authorTaub, Ethan
dc.contributor.authorSchüpbach, W.M. Michael
dc.contributor.authorPollo, Claudio
dc.contributor.authorSchkommodau, Erik
dc.contributor.authorGuzman, Raphael
dc.contributor.authorHemm-Ode, Simone
dc.date.accessioned2016-11-22T11:28:18Z
dc.date.available2016-11-22T11:28:18Z
dc.date.issued2016
dc.identifier.doi10.1007/s11517-016-1559-9
dc.identifier.urihttp://hdl.handle.net/11654/23575
dc.description.abstractDeep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient’s wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures. This method was tested on 15 tremor patients undergoing DBS surgery in two centers. Data from 359 stimulation tests were acquired. Our results suggest that accelerometric evaluation detects tremor changes more sensitively than subjective visual ratings. The effective stimulation current amplitudes identified from the quantitative data (1.1 ± 0.8 mA) are lower than those identified by visual evaluation (1.7 ± 0.8 mA) for similar improvement in tremor. Additionally, if these data had been used to choose the chronic implant position of the DBS lead, 15 of the 26 choices would have been different. These results show that our method of accelerometric evaluation can potentially improve DBS targeting.
dc.description.urihttp://link.springer.com/article/10.1007%2Fs11517-016-1559-9
dc.language.isoen
dc.relation.ispartofMBEC Medical & Biological Engineering & Computing
dc.accessRightsAnonymous
dc.subjectDeep brain stimulation
dc.subjectIntraoperative monitoring
dc.subjectEssential tremor
dc.subjectAcceleration
dc.subjectTremor
dc.subjectParkinson’s disease
dc.titleIntraoperative acceleration measurements to quantify tremor during deep brain stimulation surgery
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination1-14
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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