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dc.contributor.authorde Wild, Michael
dc.contributor.authorZimmermann, Simon
dc.contributor.authorRüegg, Jasmine
dc.contributor.authorSchumacher, Ralf
dc.contributor.authorFleischmann, Thea
dc.contributor.authorGhayor, Chafik
dc.contributor.authorWeber, Franz E.
dc.date.accessioned2016-10-21T10:07:54Z
dc.date.available2016-10-21T10:07:54Z
dc.date.issued2016
dc.identifier.issn2329-7662
dc.identifier.doi10.1089/3dp.2016.0004
dc.identifier.urihttp://hdl.handle.net/11654/23401
dc.description.abstractBone regeneration is naturally based on bone forming cells, osteoinduction by diverse growth factors, and osteoconduction. The latter one used as term in this study is the ingrowth of bone in 3D structures, which leads to an optimal case in creeping substitution of the scaffold by newly formed bone. Autologous bone is still the gold standard for bone substitutes. In most cases, newly developed bone substitutes consist of calcium phosphate, since hydroxyapatite is the main component of bone and mimics cancellous bone in microstructure. In this study, we wanted to elucidate the optimal microarchitecture for osteoconduction and determine compression strength and Young’s Modulus of the selected architectures. Selective laser melting of titanium was used as tool to generate diverse architectures in a repetitive and precise way. To link 3D scaffold architecture to biological readouts, bone ingrowth, bone to implant contact, and defect bridging of noncritical-sized defects in the calvarial bone of rabbits were determined. In this series, 5 different microarchitectures were tested with pore sizes ranging from 700 to 1300 lm and constrictions between 290 and 700 lm. To our surprise, all microstructures showed the same biological response of excellent osteoconduction. However, the mechanical yield strength of these structures differed by the factor of three and reached up to three times the strength of cancellous bone at a porosity of 72.3–88.4%. These results suggest that the microarchitecture of bone substitutes can be optimized toward mechanical strength in a wide range of constrictions and pore sizes without having a negative influence on osteoconduction.
dc.description.urihttp://online.liebertpub.com/doi/pdfplus/10.1089/3dp.2016.0004
dc.language.isoen
dc.relation.ispartof3D printing and additive manufacturing
dc.accessRightsAnonymous
dc.subjectbone substitute
dc.subjectmicroarchitecture
dc.subjectopen-porous
dc.subjectosteoconduction
dc.subjectscaffolds
dc.subjecttitanium
dc.titleInfluence of microarchitecture on osteoconduction and mechanics of porous titanium scaffolds generated by selective laser melting
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume3
dc.issue3
dc.audienceScience
fhnw.publicationStatePre-print in printing
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination143-151
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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