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Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone
Tryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, ...
A polyphenol-enriched fraction of rose oil distillation wastewater inhibits cell proliferation, migration and TNF-α-Induced VEGF secretion in human immortalized keratinocytes
Water steam distillation of rose flowers separates the essential oil from the polyphenol-containing rose oil distillation wastewater. Recently, a strategy was developed to separate rose oil distillation wastewater into a ...
Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma
An UPLC-MS/MS method for the quantification of indirubin in lithium heparinized rat plasma was developed and validated according to current international guidelines. Indirubin was extracted from rat plasma by using Waters ...
Outdoor fate and environmental impact of polymer solar cells through leaching and emission to rainwater and soil
The emission of silver and zinc to the aq. environment (rain, fog, dew) from polymer solar cells installed outdoors is presented. Studies included pristine solar cells and solar cells subjected to mech. damage under natural ...
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
Recent research has demonstrated that all body fluids assessed contain substantial amts. of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes contg. different membrane ...
Intraoperative acceleration measurements to quantify tremor during deep brain stimulation surgery
Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal ...