• Nrf2 protects stellate cells from Smad-dependent cell activation. 

      Prestigiacomo, Vincenzo; Suter-Dick, Laura (2018-07)
      Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative stress, have been shown to trigger ...
    • Rat multicellular 3D liver microtissues to explore TGF-β1 induced effects 

      Prestigiacomo, Vincenzo; Weston, Anna; Suter-Dick, Laura (2019-11-13)
      Chronic liver damage can lead to fibrosis, encompassing hepatocellular injury, activation of Kupffer cells (KC), and activation of hepatic stellate cells (HSC). Inflammation and TGF-β1 are known mediators in the liver ...