Auflistung Hochschule für Life Sciences nach Titel
Anzeige der Eintraege 1-16 von 16
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Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules
(2018-08)Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations of xenobiotics. This makes the proximal tubule a major target ... -
Network Modeling to Predict Personal Immune Scenarios
(2019-01-17) -
New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib.
(2019-02-22)PurposeLipid suspensions have been shown to be a suitablebio-enabling formulation approach for highly lipophilic or‘grease ball’drug molecules, but studies on‘brick dust’drugsare lacking. This study explored the utility ... -
The new LassoLoop360° technique for biomechanically superior tissue grip
(2019)PurposeSuprapectoral tenodesis is a frequently used technique for treating pathologies of the long head of the biceps bra-chii (LHBB) tendon. However, so far, no Gold Standard treatment exist. Hence, the arthroscopic ... -
New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials
(2018-07)Solubility parameters have been applied extensively in the chemical and pharmaceutical sciences. Particularly attractive is calculation of solubility parameters based on chemical structure and recently, new in silico methods ... -
Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress
(2016-06-01)Nodularin is produced by the cyanobacterium Nodularia spumigena. It is of concern due to hepatotoxicity in humans and animals. Here we investigated unexplored molecular mechanisms by transcription analysis in human liver ... -
Novel perfused compression bioreactor system as an in vitro model to investigate fracture healing
(2015)Secondary bone fracture healing is a physiological process that leads to functional tissue regeneration via endochondral bone formation. In vivo studies have demonstrated that early mobilization and the application of ... -
Novel polyurethane matrix systems reveal a particular release mechanism for sustained drug delivery by imaging and computational modeling
(2017)The aim of the present work was to better understand the drug-release mechanism from sustained release matrices prepared with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular ... -
Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
(2016)The aim of the present work was to better understand the drug-release mechanism from sustained release matrixes prepd. with two new polyurethanes, using a novel in silico formulation tool based on 3-dimensional cellular ... -
Nrf2 protects stellate cells from Smad-dependent cell activation.
(2018-07)Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative stress, have been shown to trigger ...