Auflistung Hochschule für Life Sciences nach Titel
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Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone
(2016)Tryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, ... -
Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations.
(2019-03-12)Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation ... -
Can iron plaque affect Sb(III) and Sb(V) uptake by plants under hydroponic conditions
(2018-04)Antimony (Sb) contamination of soils is of concern due to human activities such as recycling of Sb containing Pb acid batteries, shooting and mining. However Sb uptake by plants is poorly documented, especially when plants ... -
Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?
(2017)Self-aggregation of drugs is since many years an important topic in the pharmaceutical sciences. Drugs can aggregate similar to surfactants and thereby exhibit a critical micelle concentration (CMC). The present work focused ... -
Characterization of the housekeeping sortase from the human pathogen Propionibacterium acnes - first investigation of a class F sortase
(2019)Sortase enzymes play an important role in Gram-positive bacteria. They are responsible for the covalent attachment of proteins to the surface of the bacteria and perform this task via a highly sequence-specific transpeptidation ... -
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states.
(2019-10-01)INTRODUCTION: When developing bio-enabling formulations, innovative tools are required to understand and predict in vivo performance and may facilitate approval by regulatory authorities. EMEND® is an example of such a ... -
Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study
(2018-07)Drug-induced kidney injury is often observed in the clinics and can lead to long-term organ failure. In this work, we evaluated a novel in vitro system that aims at detecting whether compounds can cause renal proximal ... -
Comparative effects of nodularin and microcystin-LR in zebrafish: 1. Uptake by organic anion transporting polypeptide Oatp1d1 (Slco1d1)
(2016-02)Microcystin-LR (MC-LR) and nodularin are hepatotoxins produced by several cyanobacterial species. Their toxicity is based on active cellular uptake and subsequent inhibition of protein phosphatases PP1/2A, leading to ... -
Comparison of methods to assess the integrity and separation efficiency of ultrafiltration membranes in wastewater reclamation processes
(2018-06)Membrane filtration is used in many water reuse applications, thanks to its high separation efficiency with regard to particles, bacteria, cysts and in the case of ultrafiltration even viruses. However, the separation ... -
Container Closure Integrity Testing of Prefilled Syringes,
(2018-08)Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs) for injectable drug products when facilitated or self-administration is required. However, PFSs are more complex compared ... -
Continuous Processes and Flow Chemistry at the Universities of Applied Sciences in Switzerland
(2017-08)This article provides an overview of activities in the fields of continuous processes, flow chemistry and microreactors at the Universities of Applied Sciences in Switzerland. -
Continuous flow adsorption of phenolic compounds from olive mill wastewater with resin XAD16N: life cycle assessment, cost–benefit analysis and process optimization
(2019)Olive mill wastewaters (OMWs) represent a major environmental concern due to their high organic loadand phytotoxic activity. The selective recovery of phenolic compounds (PCs) from OMW is promising, thanks to the antioxidantand ... -
Corrective Osteotomy for Symptomatic Clavicle Malunion Using Patient-specific Osteotomy and Reduction Guides
(2017-09)Midshaft clavicular fractures are often treated nonoperatively with good reported clinical outcome in a majority of patients. However, malunion with shortening of the affected clavicle is not uncommon. Shortening of the ... -
Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations
(2016-09-12)Synthetic corticosteroids may pose an environmental risk to fish. Here, we describe multiend point responses of adult zebrafish (8 months old) upon 21-day exposure to a commonly prescribed corticosteroid, fludrocortisone ... -
Cost assessment of different routes for phosphorus recovery from wastewater using data from pilot and production plants
(2017-03)Phosphorus recovery from wastewater has considerable potential to supplement limited fossil phosphorus reserves. Reliable cost data are essential for investor and policymaker decisions. In this study, investment and ...